CRISPR: the simplest explanation ever

CRISPR is a technology that enables scientists to edit DNA by removing, adding or changing part of a DNA sequence.

It is currently the simplest and most precise method of genetic manipulation.

How does it work?

CRISPR-Cas9 editing uses a protein that can cut DNA (so pieces of DNA can be added or removed) and a guide RNA that identifies where to cut.

So, the Cas9 follows the guide RNA to a specific location in the DNA sequence and then makes a cut across both strands of the DNA.

The cell recognizes that the DNA is damaged and tries to repair it.

Here’s a TED talk describing how it works.

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